Entries by ImmProNano

A novel immunization approach for dengue infection based on conserved T cell epitopes formulated in calcium phosphate nanoparticles

Hum Vaccin Immunother. 2017 Nov 2;13(11):2612-2625. doi: 10.1080/21645515.2017.1369639. Epub 2017 Sep 21. Huang X1, Karabudak A1, Comber JD1, Philip M1, Morcol T2, Philip R1. 1 Immunotope, Inc. , Doylestown , PA , USA. 2 Captivate Pharmaceuticals , Doylestown , PA , USA. Abstract Dengue virus (DV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in […]

Dengue virus specific dual HLA binding T cell epitopes induce CD8+ T cell responses in seropositive individuals.

Hum Vaccin Immunother. 2014;10(12):3531-43. doi: 10.4161/21645515.2014.980210. Comber JD1, Karabudak A, Huang X, Piazza PA, Marques ET, Philip R. 1a Immunotope Inc ; Doylestown , PA USA. Abstract Dengue virus infects an estimated 300 million people each year and even more are at risk of becoming infected as the virus continues to spread into new areas. […]

MHC Class I Presented T Cell Epitopes as Potential Antigens for Therapeutic Vaccine against HBV Chronic Infection.

Hepat Res Treat. 2014;2014:860562. doi: 10.1155/2014/860562. Epub 2014 May 26. Comber JD1, Karabudak A1, Shetty V2, Testa JS3, Huang X1, Philip R1. 1Immunotope, Inc., Doylestown, PA 18902, USA. 2Baylor College of Medicine, Houston, TX 77030, USA. 3Celldex Therapeutics, Hampton, NJ 08827, USA.   Abstract Approximately 370 million people worldwide are chronically infected with hepatitis B virus (HBV). […]

Autoantibody biomarkers identified by proteomics methods distinguish ovarian cancer from non-ovarian cancer with various CA-125 levels.

J Cancer Res Clin Oncol. 2013 Oct;139(10):1757-70. doi: 10.1007/s00432-013-1501-6. Epub 2013 Sep 3. Karabudak AA1, Hafner J, Shetty V, Chen S, Secord AA, Morse MA, Philip R. Abstract PURPOSE: CA-125 has been a valuable marker for detecting ovarian cancer, however, it is not sensitive enough to detect early-stage disease and not specific to ovarian cancer. […]

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PLoS One. 2012;7(11):e48484. doi: 10.1371/journal.pone.0048484. Epub 2012 Nov 7. Testa JS1, Shetty V, Hafner J, Nickens Z, Kamal S, Sinnathamby G, Philip R. 1Immunotope, Inc., Doylestown, PA, USA. Abstract Influenza virus infection and the resulting complications are a significant global public health problem. Improving humoral immunity to influenza is the target of current conventional influenza […]

Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics.

Clin Proteomics. 2012 Aug 2;9(1):10. doi: 10.1186/1559-0275-9-10. Shetty V1, Hafner J, Shah P, Nickens Z, Philip R. 1Immunotope, Inc,, 3805 Old Easton Road, Doylestown, PA, 18902, USA. Abstract BACKGROUND: In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as […]

Quantitative immunoproteomics analysis reveals novel MHC class I presented peptides in cisplatin-resistant ovarian cancer cells.

J Proteomics. 2012 Jun 18;75(11):3270-90. doi: 10.1016/j.jprot.2012.03.044. Epub 2012 Apr 3. Shetty V1, Nickens Z, Testa J, Hafner J, Sinnathamby G, Philip R. 1Immunotope, Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States.   Abstract Platinum-based chemotherapy is widely used to treat various cancers including ovarian cancer. However, the mortality rate for patients with […]

Investigation of plasma biomarkers in HIV-1/HCV mono- and coinfected individuals by multiplex iTRAQ quantitative proteomics.

OMICS. 2011 Oct;15(10):705-17. doi: 10.1089/omi.2011.0004. Shetty V1, Jain P, Nickens Z, Sinnathamby G, Mehta A, Philip R. 1Immunotope, Inc., Pennsylvania Biotechnology Center, Doylestown, Pennsylvania, USA. Abstract The analysis of plasma samples from HIV-1/HCV mono- and coinfected individuals by quantitative proteomics is an efficient strategy to investigate changes in protein abundances and to characterize the proteins […]

MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response.

J Proteomics. 2011 May 1;74(5):728-43. doi: 10.1016/j.jprot.2011.02.020. Epub 2011 Mar 11. Shetty V1, Sinnathamby G, Nickens Z, Shah P, Hafner J, Mariello L, Kamal S, Vlahović G, Lyerly HK, Morse MA, Philip R. 1Immunotope Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA. Abstract The development of potent cancer vaccines for common malignancies such as […]

Investigation of sialylation aberration in N-linked glycopeptides by lectin and tandem labeling (LTL) quantitative proteomics.

Anal Chem. 2010 Nov 15;82(22):9201-10. doi: 10.1021/ac101486d. Epub 2010 Oct 5. Shetty V1, Nickens Z, Shah P, Sinnathamby G, Semmes OJ, Philip R. 1Immunotope, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, USA. Abstract The accuracy in quantitative analysis of N-linked glycopeptides and glycosylation site mapping in cancer is critical to the fundamental question of […]